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The original item was published from 2/3/2023 3:22:13 PM to 2/11/2023 12:00:00 AM.

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Posted on: February 3, 2023

[ARCHIVED] CDC HEALTH ADVISORY: Outbreak of Extensively Drug-resistant Pseudomonas aeruginosa

CDC Health Advisory - Red Background


Distributed via the CDC Health Alert Network 

February 1, 2023, 7:00 PM ET

Outbreak of Extensively Drug-resistant Pseudomonas aeruginosa Associated with Artificial Tears


The Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network (HAN) Health Advisory about infections with an extensively drug-resistant strain of Verona Integron-mediated Metallo-β-lactamase (VIM) and Guiana-Extended Spectrum-β-Lactamase (GES)-producing carbapenem-resistant Pseudomonas aeruginosa (VIM-GES-CRPA) in 12 states. 

Most patients reported using artificial tears. Patients reported more than 10 different brands of artificial tears, and some patients used multiple brands. 

The majority of patients who used artificial tears reported using EzriCare Artificial Tears, a preservative-free, over-the-counter product packaged in multidose bottles. CDC laboratory testing identified the presence of the outbreak strain in opened EzriCare bottles with different lot numbers collected from two states. 

Patients and healthcare providers should immediately discontinue using EzriCare artificial tears pending additional guidance from CDC and the Food and Drug Administration (FDA).

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